What is mitotic index used for

The mitotic index is a measure of cellular proliferation. It is defined as the percentage of cells undergoing mitosis in a given population of cells. Mitosis is the division of somatic cells into two daughter cells. Durations of the cell cycle and mitosis vary in different cell types. An elevated mitotic index indicates more cells are dividing.

This application note describes the use of the FlowSight® imaging flow cytometer for in-depth analysis and characterization of the cell cycle as well as the  mitotic index. the percentage of cells simultaneously in the process of division, normally calculated after counting 1000 cells. Used in morbid pathology as a measure of the malignancy of a tumor, and in clinical pathology as an index of survival time of a neoplasm. The mitotic index is a measure of cellular proliferation. It is defined as the percentage of cells undergoing mitosis in a given population of cells. Mitosis is the division of somatic cells into two daughter cells. Durations of the cell cycle and mitosis vary in different cell types. An elevated mitotic index indicates more cells are dividing. mitotic index listen (my-TAH-tik IN-dex) In a population of cells, the ratio of the number of cells undergoing mitosis (cell division) to the number of cells not undergoing mitosis. Mitotic rate is used to help find the stage of melanoma (a type of skin cancer) and other types of cancer. Higher mitotic rates are linked with lower survival rates . Also called MR. The mitotic index, the number of metaphase cells scored, the number of aberrations per metaphase cell, and the percentage of cells with structural chromosomal aberration(s) should be calculated for each animal. Different types of structural chromosomal aberrations should be listed with their numbers and frequencies.

J Chem Ecol 26(9):2079–2094, 2000), although as has been said, it can be also used to measure the mitotic activity of other organs. Mitotic index is used to 

Examples of mitotic inhibitors frequently used in the treatment of cancer include paclitaxel, docetaxel, vinblastine, vincristine, and vinorelbine. Colchicine and griseofulvin are mitotic inhibitors used in the treatment of gout and toenail fungus, respectively. Mitotic index is a number used to determine if a sample of cells could be cancerous. A high number indicates that an abnormal number of cells are undergoing mitosis. February 23, 2018 Mitotic inhibitors affect cancer cells more than normal cells because cancer cells divide (mitotic cell division) more rapidly therefore are more susceptible to mitotic inhibition. Different mitotic inhibitors are used to treat particular types of cancers, such as leukemia , lymphoma, breast cancer , lung cancer and other types of cancers. Mitotic index (MI) is an indirect measure of cell proliferation based on the quantification of mitotic figures in a histopathologic specimen and is easier to perform than AgNOR and Ki-67 assessment, which both require additional staining techniques and may necessitate the use of automated image analysis that is not currently widely available. The mitoses must be counted in an area of the highest mitotic activity. Visually identifying these areas is difficult in tumors with very high mitotic activity. Also, the detection of atypical forms of mitosis can be used both as a diagnostic and prognostic marker.

The methodology for determination of mitotic index (MI) from apical meristems of conifers was improved to population undergoing mitosis, has been used to 

Mitotic index is a number used to determine if a sample of cells could be cancerous. A high number indicates that an abnormal number of cells are undergoing mitosis. February 23, 2018 Mitotic inhibitors affect cancer cells more than normal cells because cancer cells divide (mitotic cell division) more rapidly therefore are more susceptible to mitotic inhibition. Different mitotic inhibitors are used to treat particular types of cancers, such as leukemia , lymphoma, breast cancer , lung cancer and other types of cancers. Mitotic index (MI) is an indirect measure of cell proliferation based on the quantification of mitotic figures in a histopathologic specimen and is easier to perform than AgNOR and Ki-67 assessment, which both require additional staining techniques and may necessitate the use of automated image analysis that is not currently widely available. The mitoses must be counted in an area of the highest mitotic activity. Visually identifying these areas is difficult in tumors with very high mitotic activity. Also, the detection of atypical forms of mitosis can be used both as a diagnostic and prognostic marker.

The mitotic index can be used as a prognostic tool for predicting the response of cancer cells to chemotherapy. This is especially useful in the case of breast 

J Chem Ecol 26(9):2079–2094, 2000), although as has been said, it can be also used to measure the mitotic activity of other organs. Mitotic index is used to  The methodology for determination of mitotic index (MI) from apical meristems of conifers was improved to population undergoing mitosis, has been used to  1 Apr 2013 Immunohistochemical staining for Bcl2 was performed on tissue microarrays of a total of 151 male breast cancer cases. Mitotic index was scored. have used the mitotic index technique, whereby propor- tions of cells in mitosis and cytokinesis are determined. Usually the two stages identified are cells with  12 Mar 2014 A mitotic staining is used to easily recognise which cells are in a "mitotic state". Then, the use of an automated microscope allows us to acquire  Two-dimensional FACS scanning allows the differential quantitation of G2 and mitotic cells. Several antibodies to different mitotic markers have been used in the  

mitotic index listen (my-TAH-tik IN-dex) In a population of cells, the ratio of the number of cells undergoing mitosis (cell division) to the number of cells not undergoing mitosis.

This application note describes the use of the FlowSight® imaging flow cytometer for in-depth analysis and characterization of the cell cycle as well as the  mitotic index. the percentage of cells simultaneously in the process of division, normally calculated after counting 1000 cells. Used in morbid pathology as a measure of the malignancy of a tumor, and in clinical pathology as an index of survival time of a neoplasm. The mitotic index is a measure of cellular proliferation. It is defined as the percentage of cells undergoing mitosis in a given population of cells. Mitosis is the division of somatic cells into two daughter cells. Durations of the cell cycle and mitosis vary in different cell types. An elevated mitotic index indicates more cells are dividing. mitotic index listen (my-TAH-tik IN-dex) In a population of cells, the ratio of the number of cells undergoing mitosis (cell division) to the number of cells not undergoing mitosis. Mitotic rate is used to help find the stage of melanoma (a type of skin cancer) and other types of cancer. Higher mitotic rates are linked with lower survival rates . Also called MR. The mitotic index, the number of metaphase cells scored, the number of aberrations per metaphase cell, and the percentage of cells with structural chromosomal aberration(s) should be calculated for each animal. Different types of structural chromosomal aberrations should be listed with their numbers and frequencies. Well, generally, a lower mitotic index is better. Fewer dividing cells = a less aggressive cancer. For grade 2 mast cell tumors, the magical number to hope for is a mitotic index of 5 or less. These dogs, with conventional care alone, have a median survival time of 70 months, or nearly six years.

mitotic index listen (my-TAH-tik IN-dex) In a population of cells, the ratio of the number of cells undergoing mitosis (cell division) to the number of cells not undergoing mitosis. Mitotic rate is used to help find the stage of melanoma (a type of skin cancer) and other types of cancer. Higher mitotic rates are linked with lower survival rates . Also called MR. The mitotic index, the number of metaphase cells scored, the number of aberrations per metaphase cell, and the percentage of cells with structural chromosomal aberration(s) should be calculated for each animal. Different types of structural chromosomal aberrations should be listed with their numbers and frequencies. Well, generally, a lower mitotic index is better. Fewer dividing cells = a less aggressive cancer. For grade 2 mast cell tumors, the magical number to hope for is a mitotic index of 5 or less. These dogs, with conventional care alone, have a median survival time of 70 months, or nearly six years. The mitotc index is used often in the diagnosis and treatment of cancer. Careful examination of tissue secretions made from tissues and organs from cancer patients, allows the pathologist, from a count of the number of cells in mitosis, to determine, or at least estimate, how fast a cancer is growing. The mitotic index can also be used to quantify differences in cell division when an environmental parameter is changed. Plants grown in space in microgravity had a greater mitotic index than control plants grown on the ground. The mitotic index is used for tumor grading of breast and ovarian cancers [8,9]. In addition, mitotic index has been incorporated in the American Joint Committee on Cancer (AJCC) seventh tumor staging system for malignant melanoma, gastrointestinal tumor, and neuroendocrine tumors of the gastrointestinal tract .